Acetyl Hexapeptide-3
$156.00 $106.00
Size: 200mg
Contents: Acetyl Hexapeptide-3 (Argireline)
Form: Lyophilized powder
Purity: >99%
SKU: P-ACETYL-HEXAPEPTIDE-3
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Acetyl Hexapeptide-3: A Focus on Neuromuscular Modulation and Skin Health 🔬
What is Acetyl Hexapeptide-3?
Acetyl Hexapeptide-3 (also known as Acetyl Hexapeptide-8 or Argireline) is a synthetic peptide that consists of six amino acids. It's primarily researched for its potential to reduce wrinkle formation in skin tissues. The peptide is considered a competitive SNAP25 inhibitor, designed to mimic the N-terminal end of the SNAP-25 protein, a key component of the SNARE complex. The SNARE complex is a central regulator of synaptic vesicle exocytosis, a process that releases signaling molecules for communication between nerve and muscle cells. By apparently inhibiting the formation of this complex, Acetyl Hexapeptide-3 may block the release of acetylcholine, a neurotransmitter involved in muscle contractions. Conducting research with this peptide is considered a less invasive alternative to bacterial toxins because it may act directly on superficial muscles through the skin.
Key Areas of Scientific Research 🧪
1. Acetyl Hexapeptide-3 and Wrinkles
Acetyl Hexapeptide-3 was apparently designed to mimic the action of BoNTs (botulinum neurotoxins) and pass through skin layers. A study on 10 subjects showed that an emulsion containing the peptide led to an apparent reduction in wrinkle depth by up to 30% after 30 days. Another study with 24 subjects reported similar anti-wrinkle activity and a potential decrease in transepidermal water loss (TEWL), indicating increased skin hydration. Furthermore, a clinical study with 52 subjects found improved skin wrinkle morphology and hydration. Another clinical study reported that the total anti-wrinkle efficiency was 48.9%, and wrinkle depth was notably reduced in the peptide group compared to a placebo. Experiments in aged murine models showed an apparent improvement in the histological structure of skin tissue, with an increase in type I collagen fibers and a decrease in type III collagen fibers, suggesting the peptide might rejuvenate aging skin.
2. Acetyl Hexapeptide-3 and Muscle Spasms
The peptide has been studied for its potential to address involuntary muscle spasms like blepharospasms (involuntary eyelid contractions). In a study involving 24 subjects, the active group showed a trend for a longer period until the return of the spasm (3.7 months) compared to the placebo group (3.0 months). The active group also tended to have lower scores on the Jankovic Blepharospasm Rating Scale (JBRS).
3. Acetyl Hexapeptide-3 and Scarring
A retrospective study suggests that Acetyl Hexapeptide-3 may support the mitigation of scar tissues. This potential effect is thought to be related to its ability to minimize the production of collagen type 3 fibers, which are typical for scar tissues and have low elasticity. The study reported an increase in scar tissue elasticity from 33.5% to 40.5% in certain areas.
4. Acetyl Hexapeptide-3 and Pain Perception
The palmitoylated version of Acetyl Hexapeptide-3, known as DD04107, has been studied for its potential analgesic activity in chronic inflammatory and neuropathic pain models. It was suggested to potentially block the inflammatory recruitment of ion channels and the release of calcitonin gene-related peptides, which may result in anti-hyperalgesia and anti-allodynia. The peptide might hinder the release of pain-related neuromodulators by disrupting SNAP-25 activity, possibly preventing the activation of TRPV1 channels. In carrageenan-induced inflammation models, the palmitoylated peptide has been proposed to exhibit anti-inflammatory effects, with a decrease in paw swelling and reduced mechanical sensitivity. It has also been observed to apparently reduce thermal hyperalgesia and mechanical allodynia in models of chronic inflammatory pain.
Product Specifications 📊
Molecular formula: C34H60N14O12S
Molecular weight: 888.99 g/mol
Other known titles: Acetyl Hexapeptide-8, Argireline
Important Notice: Acetyl Hexapeptide-3 is available for research and laboratory purposes only.