Follistatin-344 (1mg)
$129.00 $108.00
Follistatin-344 Product Information
Our Follistatin-344 is a high-purity, synthetic peptide available in a 1mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU is P-FOLLISTN-1.
Pricing and Discounts:
5-8 units: A 5% discount is applied, with a price of $131.10 per unit.
9+ units: A 10% discount is applied, with a price of $124.20 per unit.
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Follistatin-344 is a synthetic version of the naturally occurring Follistatin-344 protein, a glycoprotein found in most tissues. It's a subject of research for its potential to modulate cellular growth and differentiation, primarily through its binding to proteins in the Transforming Growth Factor-beta (TGFβ) superfamily. It is theorized to be an autocrine chemical, binding to receptors on the same cells that produce it to induce a cellular change.
Key Areas of Scientific Research 🧪
1. Muscle Development
Follistatin-344's most researched potential lies in its interaction with myostatin (Growth Differentiation Factor 8 or GDF8). Myostatin is a protein that acts as a natural inhibitor of muscle growth. Research in mice suggests that Follistatin-344 binds to myostatin, potentially inhibiting its function. A study in mice found that those exposed to Follistatin-344 had increased skeletal muscle mass, which appeared to result from a combination of muscle cell hyperplasia and hypertrophy.
Additionally, Follistatin-344 is also thought to inhibit activin A, another protein in the TGFβ family that negatively influences muscle growth. By potentially inhibiting both myostatin and activin A, Follistatin-344 may have a broader effect on muscle development compared to substances that only target myostatin.
2. Cellular Growth and Proliferation
Follistatin-344 has shown a complex and sometimes contradictory role in cellular proliferation.
Cancer Research: In studies on breast cancer cells, Follistatin was reportedly under-expressed, leading to the increased spread of cancer cells. Researchers posit that restoring Follistatin levels might prevent activin-induced metastasis. Additionally, Follistatin's potential to inhibit Bone Morphogenetic Proteins (BMPs) could offer a protective role against the over-proliferation of cells in esophageal cancer.
Liver & Hair: Research on rats suggests that Follistatin-344 may decrease liver fibrosis and hepatocytic apoptosis, indicating a potential protective effect on liver tissue. The peptide has also been studied for its potential to stimulate hair growth by stimulating interfollicular stem cells, with a clinical study reporting improved hair thickness and density.
3. Diabetes and Pancreatic Health
When presented to diabetic mice models, Follistatin-344 appeared to lead to the overexpression of the protein in pancreatic cells. This was reportedly associated with increased pancreatic beta cell (β-cell) mass, which are responsible for producing insulin. This is thought to be a result of the peptide's inhibition of SMAD2/3 signaling, which indirectly activates the insulin-PI3K-Akt pathway, a critical pathway for cell growth and survival.
Product Specifications 📊
Molecular Formula: N/A
Molecular Weight: 3780 g/mol
Other Known Titles: Activin-Binding Protein, FSH-Suppressing Protein, FST
Important Notice: Follistatin-344 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.