FOXO4-DRI (10mg)
$225.00 $205.00
FOXO4-DRI Product Information
Our FOXO4-DRI is a high-purity, synthetic peptide available in a 10mg size. Provided in a lyophilized powder form with a certified purity of >99%, it is intended for research purposes. The SKU is P-FOXO4-10.
Pricing and Discounts:
5-8 units: A 5% discount is applied, with a price of $223.25 per unit.
9+ units: A 10% discount is applied, with a price of $211.50 per unit.
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FOXO4-DRI, or Proxofim, is a synthetic peptide that is a modified version of the naturally occurring FOXO4 protein. It is a D-Retro-Inverso peptide, meaning its amino acids are arranged in a "reversed" sequence with D-amino acids instead of the natural L-amino acids. This modification makes it more resistant to degradation, potentially increasing its stability. The main area of research for FOXO4-DRI is its potential to selectively induce programmed cell death (apoptosis) in senescent cells, which are aged, non-dividing cells that contribute to tissue aging.
Mechanisms of Action and Research 🧪
1. Selective Apoptosis of Senescent Cells
The core function of FOXO4-DRI is to inhibit the interaction between the natural FOXO4 protein and p53 protein. In senescent cells, FOXO4 often binds to p53, preventing it from carrying out its function as a tumor suppressor and apoptosis regulator. By disrupting this bond, FOXO4-DRI may "unleash" p53, allowing it to trigger apoptosis in these dysfunctional cells. This selective clearance of senescent cells is hypothesized to improve tissue function and reduce biomarkers of aging.
2. Senescence and Longevity
Research on aged mouse models suggests that FOXO4-DRI may improve overall health metrics, including increased fitness, improved renal function, and better fur density. This is thought to be a result of the peptide's potential to reduce the burden of senescent cells, which contribute to a pro-inflammatory environment through the senescence-associated secretory phenotype (SASP).
3. Hypogonadism
In a study on male mice with age-related hypogonadism, FOXO4-DRI was presented to senescent Leydig cells (cells crucial for testosterone production). The peptide appeared to block FOXO4 and allow p53 to induce apoptosis in these aged cells, potentially alleviating dysfunction and improving testosterone synthesis.
4. Other Research Areas
Insulin Signaling: FOXO4's activities are often linked to the insulin and insulin-like growth factor signaling (IIS) pathway, suggesting it may mediate how cells respond to stress and growth signals, potentially influencing longevity.
Oxidative Stress: Natural FOXO4 may regulate the cellular response to oxidative stress by activating the transcription of antioxidant enzymes. Research suggests that FOXO4-DRI may inhibit this process, but primarily in senescent cells.
Neurological Function: The FOXO family of proteins may be altered in neurodegenerative disorders. Research hypothesizes that FOXO4-DRI could help regulate these protein levels, potentially mitigating the progression of such disorders.
Product Specifications 📊
Molecular Formula: C228H388N86O64
Molecular Weight: 5358.05 g/mol
Other Known Titles: Proxofim, Forkhead box protein O4, FOXO4a, AFX, AFX1, MLLT7
Important Notice: FOXO4-DRI peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.