GHRP-2 (5mg / 10mg)
$15.00 - $25.00
GHRP-2 Product Information
Our GHRP-2 is a high-purity, synthetic peptide available in both 5mg and 10mg sizes. Provided in a lyophilized powder form with a certified purity of >99%, it is intended for research purposes. The SKU is P-GHRP2.
Pricing and Discounts:
5-8 units: A 5% discount is applied, with prices ranging from $19.00 - $27.55.
9+ units: A 10% discount is applied, with prices ranging from $18.00 - $26.10.
We offer FREE shipping on all orders over $200.
GHRP-2 (Growth Hormone-Releasing Peptide 2) is a synthetic peptide, a pentapeptide, that is being researched for its potential to stimulate the secretion of growth hormone (GH). It is analogous to the endogenous neurotransmitter met-enkephalin but primarily works by activating the ghrelin receptors (GHS-Rs), also known as growth hormone secretagogue receptors.
Mechanisms of Action and Research 🔬
1. Growth Hormone Synthesis
GHRP-2's main area of research is its potential to induce GH secretion.
Mechanism: The peptide is believed to activate GHS-Rs on the pituitary gland, which may trigger a cascade of intracellular events involving G-proteins, phospholipase C (PLC), and the release of calcium ions, ultimately leading to the secretion of stored GH. This process may also involve the activation of cyclic AMP (cAMP) to further enhance GH synthesis.
Studies: Clinical trials have suggested that GHRP-2 may induce a significant increase in peak GH levels, with one trial reporting a 181-fold higher spike in GH production. Prolonged exposure was also suggested to increase GH levels by 3- to 5-fold and raise insulin-like growth factor-1 (IGF-1) levels.
2. Appetite Regulation
GHRP-2 is posited to influence appetite by activating ghrelin receptors in the nervous system.
Mechanism: By engaging GHS-Rs, GHRP-2 may enhance the synthesis of hunger-promoting neuropeptides like Neuropeptide Y (NPY) and Agouti-related peptide (AgRP) while possibly inhibiting the secretion of the appetite-reducing hormone, melanocyte-stimulating hormone (α-MSH). This action may also affect the brain's reward system, potentially increasing the drive for food consumption.
Studies: In a study, research models exposed to GHRP-2 were reported to have eaten an average of 36% more than the placebo group, suggesting a role for the peptide in regulating eating behavior.
3. Muscle and Body Composition
Muscle Tissues: Studies on murine models with thermal injuries suggested that GHRP-2 may reduce pro-inflammatory markers and the activity of ubiquitin ligases, which are associated with muscle wasting. This indicates a potential muscle-sparing action. Case studies have also suggested that the peptide may lead to muscle and weight gain.
Diagnostics: GHRP-2 has been explored as a diagnostic tool for GH deficiency (GHD). Studies have shown that it may induce a significant and reproducible increase in serum GH levels in individuals with GHD.
4. Anti-inflammatory and Antioxidative Actions
Oxidative Stress: Research suggests that GHRP-2 may have antioxidative potential by possibly limiting the cellular absorption of oxidized low-density lipoprotein (OxLDL). Studies on mouse models have shown a reduction in superoxide production in the aorta and a decrease in the expression of inflammatory genes.
Inflammation: In studies on murine models with acute lung injury, GHRP-2 appeared to reduce lung edema, neutrophil infiltration, and the levels of pro-inflammatory cytokines, while also suppressing the activation of nuclear factor-kappaB (NF-κB), a key mediator of inflammation.
Product Specifications 📊
Molecular Formula: C45H55N9O6
Molecular Weight: 817.97 g/mol
Other Known Titles: pralmorelin
Important Notice: GHRP-2 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.