Gonadorelin (GnRH) (10mg)
$95.00 $56.00
Gonadorelin Product Information
Our Gonadorelin is a high-purity, synthetic peptide available in a 10mg size. It is provided in a lyophilized powder form with a certified purity of >99%, suitable for research purposes. The SKU is P-GONADRLN-10.
Pricing and Discounts:
5-8 units: A 5% discount is applied, with a price of $85.50 per unit.
9+ units: A 10% discount is applied, with a price of $81.00 per unit.
We also offer FREE shipping on all orders over $200.
Gonadorelin is a synthetic peptide that mimics the naturally occurring gonadotropin hormone-releasing hormone (GnRH). It is composed of ten amino acids and is considered a GnRH agonist. Its primary research focus is on its potential to regulate the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland, which are crucial for endocrine and reproductive functions.
Key Research Areas 🔬
1. Post-Cycle and Testicular Function
HPG Axis Recovery: Gonadorelin has been studied for its potential to speed up the recovery of the hypothalamic-pituitary-gonadal (HPG) axis after the use of exogenous androgens. One study showed short-term exposure led to increased levels of LH, FSH, and endogenous testosterone, and these improvements appeared to be sustained.
Hypothalamic Dysfunction: Research on models with hypothalamic dysfunction suggested that intermittent Gonadorelin exposure may "kick-start" the HPG axis, potentially leading to successful spermatogenesis.
Testicular Descent: Researchers posit that the peptide may have a success rate of about 40% in facilitating the descent of testes, a process related to the maturation of the HPG axis.
2. Cancer Research
Gonadorelin is being explored for its potential role in cancer.
Breast Cancer: Excessive exposure to mitogens like estrogen and progesterone may increase the risk of breast cancer. GnRH agonists like Gonadorelin are hypothesized to potentially reduce the substrate for estrogen synthesis, thereby mitigating the action of these mitogens.
Prostate Cancer: The development of carcinogenic cells from prostate cells may depend on testosterone and dihydrotestosterone levels. By potentially downregulating GnRH receptors, Gonadorelin may lead to a decline in the production of these hormones.
3. Spermatogenesis and Contraception
Sperm Count: A clinical trial using a GnRH analog similar to Gonadorelin, combined with testosterone replacement therapy (TRT), suggested a significant reduction in average sperm count (up to 93%). In some subjects, this led to azoospermia (complete absence of sperm). This effect appeared to be reversible after the study concluded, leading researchers to hypothesize its potential as a temporary male contraceptive.
4. Neuroprotection
Research suggests that LH may have a negative impact on the hippocampus, the brain's memory center. Researchers posit that inhibiting LH production with GnRH analogs like Gonadorelin may be a way to mitigate neurological dysfunction. However, testosterone, which is also affected by this pathway, has been studied for its potential to preserve memory function.
Product Specifications 📊
Molecular Formula: C55H75N17O13
Molecular Weight: 1182.31 g/mol
Other Known Titles: Growth Hormone Releasing Factor, Somatocrinin, Somatoliberin
Important Notice: Gonadorelin peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.