Humanin (10mg)
$132.00 $107.00
Humanin Product Information
Our Humanin is a high-purity, synthetic peptide available in a 10mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU is P-HUMANIN-10.
Pricing and Discounts
5-8 units: A 5% discount is applied, with a price of $139.65 per unit.
9+ units: A 10% discount is applied, with a price of $132.30 per unit.
We also offer FREE shipping on all orders over $200.
Sources
Humanin is a naturally occurring peptide that is the subject of research for its potential role in cell metabolism and neuroprotective functions. It is encoded by a mitochondrial gene, and its length may vary depending on where it's synthesized.
Key Research Areas 🔬
1. Cellular and Mitochondrial Protection
Humanin is being researched for its potential to protect cells and mitochondria from damage.
Apoptosis Inhibition: It is posited to bind to intracellular molecules like the Bax protein, which is involved in apoptosis (programmed cell death). By binding to the inactive form of Bax, Humanin may prevent the changes that lead to cellular death.
Mitochondrial Function: Studies suggest that Humanin may inhibit reactive oxygen species (ROS), thereby mitigating mitochondrial degeneration. In retinal pigment epithelial cells exposed to oxidative stress, the peptide was posited to restore mitochondrial bioenergetics.
Hypoxia and Ischemia: In models of hypoxia (low oxygen levels) and ischemia (restricted blood flow), Humanin was reported to protect cells and reduce tissue damage. One study on cerebral ischemia suggested that Humanin may reduce infarct volume by up to 30%.
2. Neurological Deterioration
Humanin is being explored for its potential neuroprotective effects.
Memory and Learning: A study on murine models with high levels of amyloid proteins, an indicator of neurological deterioration, suggested that Humanin exposure improved memory and learning abilities.
Neurotoxin Protection: Research on cortical neurons exposed to a neurotoxin suggested that Humanin may preserve cell viability, alleviate oxidative stress, and inhibit the over-phosphorylation of tau proteins, which are associated with neurodegenerative diseases.
3. Insulin Resistance and Metabolism
Humanin has been studied for its potential effects on metabolism and insulin sensitivity.
Glucose Tolerance: In non-obese diabetic murine models, Humanin was reported to restore glucose tolerance and delay the onset of diabetes.
Weight and Energy: A study on mice fed a high-fat diet suggested that Humanin may reduce weight gain and decrease fasting glucose levels while increasing insulin levels and energy expenditure.
4. Cellular Longevity and Cancer
Cellular Longevity: Studies suggest a negative correlation between Humanin and growth hormone (GH) and insulin-like growth factor-1 (IGF-1), which are associated with accelerated aging. Murine models with increased Humanin levels and undetectable GH/IGF-1 levels reportedly had an increased lifespan.
Cancer Research: In a study on murine carcinogenesis models, a combination of an antineoplastic agent and Humanin appeared to reverse the apoptosis of healthy cells, which was otherwise induced by the antineoplastic agent alone.
Product Specifications 📊
Molecular Formula: C119H204N34O32S2
Molecular Weight: 2687.3 g/mol
Other Known Titles: HNGF6A protein
Important Notice: Humanin peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.