N-Acetyl Semax (25mg)
$49.00 $30.00
N-Acetyl Semax Product Information
Our N-Acetyl Semax is a high-purity, synthetic peptide available in a 25mg size. Provided in a lyophilized powder form with a certified purity of >99%, it is intended for research purposes. The SKU is N-Acetyl-Semax.
N-Acetyl Semax is a synthetic polypeptide that is an analog of a fragment of the naturally occurring adrenocorticotropic hormone (ACTH). It is being researched for its potential nootropic (memory-enhancing) and neuroprotective properties. The peptide is modified with a Pro-Gly-Pro (PGP) extension and an acetyl group, which may enhance its stability and ability to cross the blood-brain barrier (BBB).
1. Mechanisms of Action 🧪
N-Acetyl Semax is hypothesized to influence several key systems in the central nervous system:
Neurotransmitters: The peptide may act on serotonin, dopamine, and enkephalin levels. Research suggests it may increase a serotonin metabolite (5-HIAA), potentially enhancing serotonergic activity. It may also inhibit enkephalin-degrading enzymes, which could increase enkephalin levels. While it doesn't directly alter dopamine levels, it might modulate the system's responsiveness.
Brain-Derived Neurotrophic Factor (BDNF): Semax is believed to potentially increase BDNF expression, which is crucial for neuroplasticity and overall brain health.
Gene Expression: It may also modulate gene expression and influence the efficacy of the immune system.
2. Research and Clinical Studies 🔬
Nootropic and Anxiolytic Potential
Cognition: In a study on rodents, Semax appeared to increase 5-HIAA levels, suggesting an enhancement of the serotonergic system. It has also been reported to enhance memory and attention in models under stress.
Anxiety: Studies on models of separation anxiety and SSRI-induced anxiety suggested that Semax may reduce anxious behavior and improve learning abilities.
SSRI Interaction: When given to rats exposed to an SSRI, Semax appeared to reduce their anxiety and potentially enhance their learning abilities, suggesting a potential for modulating the effects of SSRIs on brain development.
Neuroprotection
Ischemic Stroke: In a clinical study on models of ischemic stroke, those exposed to both a conventional compound and Semax appeared to show notable improvement in restoring damaged brain activity, as seen on an electroencephalogram (EEG).
Cardiovascular System: In a study on rodents with myocardial infarction (MI), Semax appeared to prevent a reduction in diastolic blood pressure and inhibit signs of heart failure.
3. Product Information 🧬
Molecular Formula: C37H51N9O10S
Molecular Weight: 858.97 g/mol
Other known titles: ACTH (4-7)PGP, HY-P1146
Important Notice: N-Acetyl Semax peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.