P21 (5mg)
$95.00 $86.00
P21 Product Information
Our P21 is a high-purity, synthetic peptide available in a 5mg size. Provided in a lyophilized powder form with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-P21.
P21 (or P021) is a synthetic peptide that mimics the activity of ciliary neurotrophic factor (CNTF), a protein that promotes the survival and differentiation of neural cells. It's designed to activate the CNTF receptor complex and its downstream signaling pathways without triggering an allergic response, potentially leading to enhanced neurogenesis, neuronal differentiation, and improved cognition.
1. Mechanisms of Action 🧪
P21 is theorized to influence several key neurological pathways:
CNTF Receptor Activation: P21 is designed to mimic CNTF's action by binding to its receptor complex, which may initiate a cascade of signals that supports neuronal health and function.
Neurogenesis: The peptide may boost the proliferation and differentiation of adult hippocampal progenitors, leading to neurogenesis (the creation of new neurons).
Synaptic Function: P21 is hypothesized to improve synaptic plasticity by increasing levels of proteins crucial for synaptic function, such as synapsin, PSD-95, and MAP2. This may strengthen connections between neurons.
Neurotrophic Factor Expression: Research suggests that P21 may increase the expression of Brain-Derived Neurotrophic Factor (BDNF), a key protein for neuronal survival, differentiation, and the growth of dendrites.
Tau Protein Modulation: P21 may reduce total and phosphorylated tau protein levels, a hallmark of Alzheimer's disease models, possibly through indirect modulation of pathways like GSK-3.
2. Research and Clinical Studies 🔬
Cognitive Impairment and Neurodegenerative Diseases
Alzheimer's Disease Models: Studies on murine models of Alzheimer's disease (AD) suggested that P21 may rescue cognitive deficits, reverse synaptic impairment, and reduce the accumulation of amyloid-beta (Aβ) plaques and tau pathologies. When administered early, it appeared to prevent these pathologies from developing.
Cognitive Aging: In studies on aged mice, P21 appeared to reverse the natural decline in learning and memory by inhibiting neurogenesis deficits and restoring synaptic deficits in the cortex and hippocampus. Researchers suggest that P21 might be a potential research approach for cognitive aging and AD.
Other Research Areas
Macular Degeneration: P21 is being investigated for its potential to prevent pathological changes associated with age-related macular degeneration (AMD). A study on murine models suggested that chronic exposure to P21 may ameliorate several AMD-related pathological changes, including photoreceptor degeneration and inflammatory responses in the retina.
Blood-Brain Barrier: The peptide's structure, which includes adamantane building blocks, is designed to enhance its ability to cross the blood-brain barrier (BBB), making it more effective in reaching the central nervous system. The research also suggests it does not cause an immune reaction.
3. Product Information 🧬
Molecular Formula: C30H54N6O5
Molecular Weight: 578.3 g/mol
Sequence: Ac-DGGL-adamatanylglycine-NH2
Other Known Titles: P021
Important Notice: P21 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.