PE-22-28 (8mg)
$41.00 $34.00
PE-22-28 Product Information
Our PE-22-28 is a high-purity, synthetic peptide available in an 8mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-PE2228-8.
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PE-22-28 is a synthetic, seven-amino-acid peptide derived from the naturally occurring protein spadin. It's being researched for its potential antidepressant and nootropic effects, which are hypothesized to stem from its action as a blocker of the TREK-1 receptor, a potassium channel found in brain regions like the hippocampus and prefrontal cortex. Blocking this receptor may increase neuron excitability.
1. Mechanisms of Action 🧪
PE-22-28 is believed to act on several key systems in the central nervous system:
TREK-1 Receptor Inhibition: The peptide is hypothesized to specifically bind to and block the TREK-1 receptor, a two-pore potassium channel. Researchers believe this action may increase neuronal excitability and contribute to an antidepressant effect.
Neurogenesis and Synaptogenesis: The peptide may exert neurogenesis (the formation of new neurons) and synaptogenesis (the formation of new synapses). This is supported by research suggesting it may activate the MAPK and PI3K pathways and increase expression of Brain-Derived Neurotrophic Factor (BDNF).
Serotonin Signaling: PE-22-28 may influence the serotonin system, a key regulator of mood. Studies on its parent protein, spadin, suggest it may activate serotonergic neurons in the dorsal raphé nucleus, potentially facilitating serotonin transmission.
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2. Research and Clinical Studies 🔬
Depression and Mood
Antidepressant Effects: Research on brain models of depression suggests that PE-22-28 may increase the volume of the hippocampus and mitigate instances of synaptic feedback that lead to depressive episodes.
Post-Stroke Depression (PSD): In a study on mice with PSD, the peptide was reported to be fast-acting and as effective as a conventional SSRI compound, but without the additional unintended impacts that can be associated with SSRIs.
Neurogenesis and Cognitive Function
Memory and Learning: Studies on spadin suggest it may increase the number of BrdU-positive cells in the hippocampus, indicating a quick activation of neurogenic pathways. This, along with its potential to increase BDNF expression, suggests that PE-22-28 may also exhibit nootropic potential by improving memory and learning.
CREB Activation: Spadin has been shown to rapidly increase levels of phosphorylated CREB, a transcription factor critical for neuronal growth, formation, and plasticity.
3. Product Information 🧬
Molecular Formula: C35H55N11O9
Molecular Weight: 773.89 g/mol
Sequence: GVSWGLR
Important Notice: PE-22-28 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.