PTD-DBM (5mg)
$68.00 $49.00
PTD-DBM Product Information
Our PTD-DBM is a high-purity, synthetic peptide available in a 5mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is PTD-DBM.
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PTD-DBM (Protein Transduction Domain-fused Dishevelled Binding Motif) is a synthetic peptide being researched for its potential to stimulate hair follicle growth and tissue regeneration. Its proposed mechanism of action involves activating the Wnt/β-catenin signaling pathway by disrupting the interaction between the CXXC5 and Dishevelled (Dvl) proteins.
1. Mechanisms of Action 🧪
The potential actions of PTD-DBM are hypothesized to work on a cellular signaling level:
Wnt/β-catenin Pathway Activation: PTD-DBM is believed to disrupt the CXXC5-Dvl protein complex. CXXC5 is a negative regulator of the Wnt/β-catenin pathway, which is crucial for cell proliferation, differentiation, and tissue maintenance. By interfering with this negative regulation, the peptide may enhance the pathway's activity.
Stimulating Follicle Growth: The activation of the Wnt/β-catenin pathway is thought to promote hair follicle growth and induce the anagen phase (the growth phase) of the hair cycle.
Tissue Regeneration: This pathway is also critical for wound healing. PTD-DBM's potential to activate it may enhance regenerative healing, including stimulating fibroblast activity and collagen deposition.
2. Research and Clinical Studies 🔬
Hair Follicle Growth
Inhibiting Hair Loss: Research suggests that PTD-DBM may counteract hair loss induced by factors like Prostaglandin D2 (PGD2) and dihydrotestosterone (DHT), which are thought to increase CXXC5 expression.
Promoting Anagen Phase: Studies on murine models showed that PTD-DBM appeared to induce hair regrowth and also initiated wound-induced hair follicle neogenesis (WIHN), suggesting it could not only promote existing follicle growth but also help create new ones in response to injury.
Synergistic Effects: When combined with other Wnt/β-catenin activators like valproic acid (VPA), PTD-DBM appeared to show a synergistic action, with a notable increase in markers of cell proliferation.
Tissue Repair and Regeneration
Wound Healing: A study on mice with cutaneous wounds suggested that PTD-DBM may enhance the wound-healing process, and when combined with VPA, appeared to significantly induce re-epithelialization and collagen deposition.
Bone Regeneration: Preliminary research on murine models suggests that PTD-DBM may induce the formation of new bones, possibly by inhibiting the Dvl-CXXC5 interaction, which may have implications for osteoporosis research.
3. Product Information 🧬
Molecular Formula: C124H223N61O28S2
Molecular Weight: 3080.7 g/mol
Other known titles: Protein Transduction Domain-fused Dishevelled Binding Motif peptide, Hair growth peptide
Important Notice: PTD-DBM peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.
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