Receptor Grade IGF-1 LR3 (1mg)
$125.00 $105.00
Receptor Grade IGF-1 LR3 Product Information
Our Receptor Grade IGF-1 LR3 is a high-purity, synthetic peptide available in a 100mcg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-IGF1LR3-100.
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Receptor Grade IGF-1 LR3 is a high-purity, synthetic variant of Insulin-like Growth Factor-1 (IGF-1). It contains an extended 13-amino-acid N-terminal structure and has glutamic acid at residue 3 replaced with arginine. These structural changes are believed to increase its anabolic potential and reduce its binding to IGF-1 binding proteins (IGFBPs), thereby allowing it to act more freely in research settings.
1. Mechanisms of Action 🧪
Receptor Grade IGF-1 LR3's potential actions are focused on regulating cell tissue growth and development:
Anabolic Effects: The peptide is suggested to be more potent than natural IGF-1, with studies showing it may be 1.5 to 2.5 times as effective in promoting anabolic effects such as weight gain and increased visceral organ weights. It also appears to reduce markers of muscle protein breakdown more effectively than IGF-1.
Metabolic Activity: IGF-1 LR3 is thought to improve glucose metabolism and insulin sensitivity by inducing glucose uptake. This may occur through the activation of signaling mechanisms involving the PI3K and AMPK pathways.
Tissue Distribution: Its reduced binding to IGFBPs is hypothesized to allow it to clear from the serum more quickly and distribute into tissues more freely. Studies have observed increased concentrations of IGF-1 LR3 in specific organs like the kidneys, ovaries, and and adrenal glands.
Myostatin Inhibition: The peptide is suggested to counteract the negative effects of myostatin, a protein that inhibits muscle cell growth. By mitigating myostatin's action, IGF-1 LR3 may help increase lean muscle mass and prevent muscle cell apoptosis.
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2. Research and Clinical Studies 🔬
Growth Disorders: In models of growth hormone deficiency, IGF-1 analogs have been shown to increase height and length, suggesting a potential role for IGF-1 LR3 in addressing such conditions.
Cell Culture Studies: IGF-1 LR3's design is specifically optimized for cell culture studies, where it is used to evaluate its potential for regulating cell tissue and development.
Reduced IGFBP Binding: Research indicates that the modified structure of IGF-1 LR3 leads to a reduced affinity for IGFBPs, which are proteins that regulate the availability of IGFs in the body. This is thought to result in a shorter duration of action but potentially a more potent effect due to increased bioavailability.
3. Product Information 🧬
Molecular Formula: C400H625N111O115S9
Molecular Weight: 9117.5 g/mol
Other Known Titles: Long-(arg3) insulin-like growth factor-I, Insulin-like growth factor long chain R3
Important Notice: Receptor Grade IGF-1 LR3 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.