Sermorelin (5mg)
$39.00 $28.00
Sermorelin Product Information
Our Sermorelin is a high-purity, synthetic peptide available in a 5mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-SERMORELIN-5.
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Sermorelin is a 29-amino-acid synthetic peptide that is an analog of the first 29 amino acids of growth hormone-releasing hormone (GHRH). It is being researched for its potential to stimulate the pituitary gland to release growth hormone (hGH). Its structural and functional mimicry of GHRH makes it a subject of research in models of growth hormone deficiency.
1. Mechanisms of Action 🧪
Sermorelin's potential actions are centered on the endocrine system:
GHRH Receptor Binding: The peptide is hypothesized to bind to GHRH receptors on the pituitary gland. This binding is thought to activate a signaling cascade, potentially increasing cyclic adenosine monophosphate (cAMP), which in turn may stimulate the secretion of growth hormone.
Growth Hormone (hGH) Release: By activating the GHRH receptors, Sermorelin may stimulate the pituitary gland to release hGH in a sporadic, more natural manner.
IGF-1 Increase: The increased levels of hGH are believed to lead to a subsequent increase in insulin-like growth factor-1 (IGF-1), a protein primarily known for its role in the anabolic actions of growth hormone.
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2. Research and Clinical Studies 🔬
Growth and Anabolic Effects
Growth Velocity: In models of idiopathic GH deficiency, Sermorelin exposure appeared to lead to a sustained increase in growth and height velocity for up to 36 months after continuous presence.
Lean Body Mass: Studies suggest that Sermorelin may increase growth hormone levels by as much as 107% and IGF-1 levels by about 28%, which may lead to an increase in lean body mass. One study reported a gain of 2.78 lbs (1.26 kg) in lean body mass.
Lipodystrophy: In a study on HIV-positive subjects with lipodystrophy, Sermorelin appeared to significantly increase growth hormone and IGF-1 levels, resulting in increased lean body mass and a reduction in abdominal visceral fat.
Other Research Areas
Cognition: A study on elderly subjects suggested that Sermorelin might improve performance on intelligence and verbal tests, which may be linked to the potential for the peptide to counteract the age-related decline in growth hormone.
Hypogonadism: Research suggests Sermorelin may stimulate the release of FSH and LH, which might lead to an increase in testosterone production.
Tumor Cells: In a study on glioma subjects, Sermorelin appeared to induce sensitivity in tumor cells, with researchers suggesting it may block their cell cycles and prevent proliferation.
3. Product Information 🧬
Molecular Formula: C149H246N44O42S
Molecular Weight: 3357.93 g/mol
Other Known Titles: GRF 1-29
Important Notice: Sermorelin peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.