SS-31 (MTP-131) 10mg

MTP-131 (SS-31) 10mg is an extraordinary, research-grade mitochondria-targeted tetrapeptide that represents one of the most scientifically innovative, mechanistically elegant, and biologically significant peptide research compounds to emerge from the rapidly advancing field of mitochondrial medicine and bioenergetics research in recent decades. As a member of the groundbreaking Szeto-Schiller (SS) family of mitochondria-targeted peptides — developed through the pioneering research of Drs. Hazel Szeto and Peter Schiller at Weill Cornell Medical College — SS-31 has established itself as arguably the most scientifically compelling and extensively studied mitochondria-targeted research compound currently available to the global laboratory science community, consistently generating profound and far-reaching scientific interest across an impressively diverse range of biological research disciplines centered on mitochondrial function, bioenergetics, and cellular energy biology.

What makes SS-31 uniquely extraordinary among mitochondria-targeted research compounds is its remarkable and highly specific molecular mechanism of action — centered on its exceptional ability to selectively concentrate within the inner mitochondrial membrane and directly bind to cardiolipin, the signature phospholipid of the inner mitochondrial membrane that plays indispensable structural and functional roles in the organization and activity of the mitochondrial electron transport chain. This extraordinary cardiolipin-targeting specificity — achieved through the alternating aromatic and cationic amino acid architecture of the SS-31 tetrapeptide sequence — allows the compound to accumulate at concentrations within the inner mitochondrial membrane that are orders of magnitude higher than in the surrounding cytoplasm, placing it in direct physical proximity to the very molecular machinery responsible for cellular energy production.

Through its intimate association with cardiolipin at the inner mitochondrial membrane, SS-31 has been demonstrated in research settings to exert profound and far-reaching influences on electron transport chain complex activity, mitochondrial membrane potential maintenance, ATP synthesis efficiency, reactive oxygen species production regulation, mitochondrial cristae architecture, and the fundamental bioenergetic processes governing cellular energy metabolism. This remarkable capacity to directly interface with and influence the innermost workings of the mitochondrial energy production machinery at the molecular level has positioned SS-31 as an unparalleled research tool for scientists seeking to investigate mitochondrial biology, bioenergetics, and the role of mitochondrial dysfunction in cellular pathology at the most fundamental and mechanistically precise level currently achievable in the laboratory research setting.

The 10mg crystalline lyophilized formulation of MTP-131 offered by Mile High Compounds provides research teams with a precisely formulated, high-purity compound supply that is ideally suited for structured mitochondrial biology investigations, controlled bioenergetics research protocols, and comprehensive cellular energy metabolism studies requiring consistent compound availability, exceptional dosing precision, and the highest standards of crystalline peptide formulation quality and experimental reproducibility.

Research Applications:

MTP-131 (SS-31) 10mg supports an exceptionally comprehensive and scientifically pioneering range of research applications spanning mitochondrial biology, bioenergetics, oxidative stress science, aging research, cellular metabolism, and systems-level mitochondrial medicine, including:

• Cardiolipin Biology & Inner Mitochondrial Membrane Research — conducting foundational and advanced investigations into SS-31's extraordinary and highly specific cardiolipin-binding mechanism, examining how tetrapeptide-mediated cardiolipin interaction influences inner mitochondrial membrane organization, cardiolipin domain formation, mitochondrial cristae architecture maintenance, and the structural integrity of the supramolecular complexes governing electron transport chain assembly and function in controlled in vitro research models

• Electron Transport Chain Function & Bioenergetics Research — examining SS-31's well-documented influence on electron transport chain complex activity, investigating how cardiolipin-targeted tetrapeptide binding modulates the functional efficiency of Complex I, II, III, and IV, electron transfer dynamics, proton pumping activity, and the overall bioenergetic output of the mitochondrial respiratory chain in controlled laboratory research environments

• Mitochondrial Membrane Potential & ATP Synthesis Research — studying SS-31's influence on mitochondrial membrane potential (ΔΨm) maintenance, examining how cardiolipin interaction and electron transport chain activity modulation collectively influence the proton electrochemical gradient driving ATP synthase activity, ATP production efficiency, and the fundamental bioenergetic processes governing cellular energy availability in research models

• Reactive Oxygen Species Regulation & Mitochondrial Oxidative Stress Research — investigating SS-31's well-documented influence on mitochondrial ROS production, examining how inner mitochondrial membrane-targeted cardiolipin binding modulates superoxide generation at electron transport chain complex I and III, hydrogen peroxide production dynamics, and the broader mitochondrial oxidative stress regulatory mechanisms governing cellular redox homeostasis in controlled research settings

• Mitochondrial Cristae Architecture & Ultrastructure Research — exploring SS-31's documented influence on mitochondrial cristae morphology and ultrastructural organization, examining how cardiolipin-targeted tetrapeptide interaction influences cristae junction formation, membrane curvature regulation, and the spatial organization of respiratory chain supercomplexes within the inner mitochondrial membrane in laboratory research models

• Aging Biology & Mitochondrial Decline Research — conducting comprehensive investigations into SS-31's research relevance to the well-documented decline in mitochondrial function associated with biological aging, examining how cardiolipin-targeted tetrapeptide activity influences age-associated mitochondrial dysfunction, electron transport chain efficiency decline, increased ROS production, and the accumulation of mitochondrial DNA damage in research models designed to study the fundamental biology of cellular aging

• Cardiac Bioenergetics & Cardiomyocyte Biology Research — studying SS-31's extensively documented research activity in cardiac tissue biology contexts, examining how mitochondria-targeted cardiolipin interaction influences cardiomyocyte bioenergetics, cardiac ATP production efficiency, myocardial energy substrate utilization, and the mitochondrial determinants of cardiac cell function and resilience in controlled in vitro research frameworks

• Ischemia-Reperfusion Biology & Mitochondrial Stress Research — investigating SS-31's documented influence on mitochondrial responses to ischemic and reperfusion conditions, examining how cardiolipin-targeted inner mitochondrial membrane interaction modulates mitochondrial permeability transition pore opening dynamics, cytochrome c release regulation, and the mitochondrial signaling events governing cellular stress responses in laboratory research models

• Neuronal Bioenergetics & Neuroprotection Research — exploring the compelling research interest in SS-31's influence on neuronal mitochondrial function, examining how mitochondria-targeted cardiolipin interaction influences synaptic mitochondrial bioenergetics, neuronal ATP production efficiency, axonal mitochondrial transport dynamics, and the mitochondrial determinants of neurological cell energy homeostasis and functional integrity in controlled research settings

• Mitochondrial Dynamics & Quality Control Research — studying SS-31's influence on mitochondrial fusion and fission dynamics, examining how inner mitochondrial membrane cardiolipin interaction influences the regulatory mechanisms governing mitochondrial network organization, mitochondrial quality control through mitophagy, and the maintenance of a healthy and functionally competent mitochondrial population in research models

• Skeletal Muscle Bioenergetics & Exercise Metabolism Research — investigating SS-31's research relevance to skeletal muscle mitochondrial function, examining how cardiolipin-targeted tetrapeptide activity influences muscle cell ATP production capacity, mitochondrial biogenesis regulation, oxidative phosphorylation efficiency, and the mitochondrial determinants of skeletal muscle energy metabolism and functional performance in controlled laboratory research frameworks

• Comparative Mitochondria-Targeted Peptide Research — utilizing SS-31 alongside complementary mitochondria-targeted research compounds including MOTS-c, Humanin, and other SS-peptide family members in comparative research frameworks designed to map the broader landscape of mitochondria-targeted peptide biology, examining the relative contributions of different mitochondrial targeting mechanisms and molecular interactions to mitochondrial function, bioenergetics, and cellular energy metabolism research outcomes

Specifications:

Intended Use: This compound is intended strictly for in vitro laboratory research. It is not approved for use in humans or animals and must not be used in foods, drugs, supplements, or diagnostics.

Legal Disclaimer: This product and associated materials have not been evaluated by the U.S. Food and Drug Administration. No claims are made regarding diagnosis, treatment, or prevention of disease. Use is restricted to qualified professionals in certified research environments.

Terms of Sale: By purchasing from Mile High Compounds, the buyer confirms they are a qualified researcher or institution. The purchaser accepts full responsibility for proper handling, storage, usage, and compliance with applicable laws. All sales are final.