Syn-AKE (200mg)
$109.00 $96.00
Syn-AKE Product Information
Our Syn-AKE is a high-purity, synthetic peptide available in a 200mg size. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-SYN-AKE.
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Syn-AKE is a synthetic tripeptide (beta-alanyl-L-prolyl-3-aminomethyl-L-alanine benzyl amide acetic acid) designed to mimic the muscle-relaxing activity of Waglerin-1, a polypeptide found in snake venom. It is being researched for its potential anti-aging properties, specifically its ability to reduce the appearance of wrinkles and fine lines by temporarily inhibiting muscle contractions.
1. Mechanisms of Action 🧪
The potential actions of Syn-AKE are focused on modulating muscle contractions at the neuromuscular junction:
Mimicking Waglerin-1: Syn-AKE is structurally and functionally designed to mimic the activity of Waglerin-1, which is a muscle-relaxant polypeptide.
Nicotinic Acetylcholine Receptor (nAChR) Antagonism: The peptide is believed to act as an antagonist to the nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. These receptors are responsible for transmitting nerve signals that lead to muscle contraction.
Inhibiting Acetylcholine: By blocking nAChRs, Syn-AKE may prevent the uptake of acetylcholine, a neurotransmitter that triggers muscle contractions. This temporary inhibition of muscle activity is thought to reduce the depth and formation of wrinkles.
Selective Action: Unlike its natural analog Waglerin-1, which may also affect GABA receptors in the brain, initial research suggests that Syn-AKE has a more selective action on nAChRs and may not carry the same risks.
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2. Research and Clinical Studies 🔬
Wrinkle Reduction and Skin Texture
Immediate and Long-Term Effects: A three-month study on female subjects with mild-to-moderate wrinkles reported that Syn-AKE appeared to exhibit both immediate effects (within two hours of application) and long-term potential, with statistically significant improvements in wrinkles observed at months 1 and 3.
Clinical Efficacy: A study on a 4% Syn-AKE formulation reported up to a 52% reduction in the appearance of wrinkle size in the forehead area after 28 days of twice-daily application. This was a gradual process, with greater effects seen over time.
Reversible Action: Research suggests that the peptide's effects on nAChRs may be reversible, implying that its potential to reduce muscle contractions is temporary and ceases once the compound is no longer present.
3. Product Information 🧬
Molecular Formula: C23H37N5O7
Molecular Weight: 495.57 g/mol
Other Known Titles: Tripeptide-3, Syn-Ake acetate, SYN-AK, DTXSID40231699, EX-A3743
Important Notice: Syn-AKE peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.