Thymosin Alpha-1 (5mg / 10mg)
$81.00 - $149.00
Thymosin Alpha-1 Product Information
Our Thymosin Alpha-1 is a high-purity, synthetic peptide available in 5mg and 10mg sizes. Provided as a lyophilized powder with a certified purity of >99%, it is intended for research purposes. The SKU for this product is P-THYMOSA1-5-10.
Pricing and Discounts
Prices for our Thymosin Alpha-1 range from $76.95 to $141.55, depending on the size and quantity ordered. We offer tiered discounts:
5-8 units: A 5% discount is applied, with a price range of $76.95 - $141.55.
9+ units: A 10% discount is applied, with a price range of $72.90 - $134.10.
We also offer FREE shipping on all orders over $200.
Thymosin Alpha-1 (TA1), also known as Thymalfasin, is a naturally occurring polypeptide that is being researched for its potential as an immunomodulator. It is a fragment of a longer protein molecule and is thought to play a key role in the immune system, particularly in the production and function of T-cells. The synthetic form, Thymalfasin, is being studied for its potential in treating various immune-related conditions, including viral infections and sepsis.
1. Mechanisms of Action 🧪
Thymosin Alpha-1's potential actions are centered on enhancing and regulating the immune system:
T-cell Modulation: The peptide is believed to stimulate the differentiation of T-cells and the terminal differentiation of blood lymphocytes. It may also increase the expression of high-affinity receptors for interleukin-2 (IL-2), which could lead to a more vigorous activation of T-lymphocytes.
Cytokine and Immune Response: Research suggests that TA1 may increase the concentration of the major histocompatibility complex (MHC) class I and enhance the activity of natural killer (NK) cells. It is also thought to stimulate the production of various cytokines, such as IL-2 and interferon-gamma (IFN-γ), to support the adaptive immune system.
Macrophage and Thrombin Function: The peptide may enhance the efficiency of macrophages and act as a modulator of alpha-thrombin activity.
2. Research and Clinical Studies 🔬
Viral and Immune Conditions
Hepatitis: Clinical trials on subjects with Hepatitis B and C have suggested that Thymosin Alpha-1 may increase the virological response rate, especially when combined with other compounds like interferon alpha.
Sepsis: A meta-analysis of clinical trials suggested that Thymosin Alpha-1 may be associated with a significant decline in mortality rates among subjects with sepsis, possibly by alleviating immunosuppression.
HIV: In a clinical trial on HIV-positive subjects, the peptide appeared to increase signal joint T-cell receptor circles (sjTREC) levels, which may indicate a potential for immune reconstitution by enhancing thymic output.
Cancer Research
Carcinoma: In a study on mice with liver carcinoma, Thymosin Alpha-1 appeared to increase the levels of leuko-monocytes while delaying the cell cycle for cancer cells.
Lung Cancer: Research on lung cancer cells (A549) suggested that Thymosin Alpha-1 may exhibit an anti-proliferative action, reduce cellular reactive oxygen species (ROS) levels, and inhibit cell migration.
3. Product Information 🧬
Molecular Formula: C129H215N33O55
Molecular Weight: 3108.31 g/mol
Other Known Titles: TA1, Tα1, Thymalfasin
Important Notice: Thymosin Alpha-1 peptide is available for research and laboratory purposes only. It is not intended for human or veterinary use. All information provided is for educational and scientific reference only and has not been evaluated by the FDA or any medical regulatory body.